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We found one dictionary with English definitions that includes the word be on uppers:
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1. be on_uppers: Idioms [home, info]

▸ Words similar to be on uppers ▸ Usage examples for be on uppers ▸ Idioms related to be on uppers (New!) ▸ Words that often appear near be on uppers ▸ Rhymes of be on uppers ▸ Invented words related to be on uppers